A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/14 (2006.01) A61K 31/22 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 9/00 (2006.01) C07C 69/33 (2006.01)
Patent
CA 2742181
The present invention relates to a complex made up of at least one molecule of statin or a derivative thereof, covalently bonded to at least one hydrocarbon radical including at least 18 carbon atoms and containing at least one 2-methyl-buta-2-ene unit, to nanoparticles of such a complex, and to a method for preparing same, said complex and/or said nanoparticles optionally being in the form of a lyophilisate. The present invention also relates to a pharmaceutical composition including at least one complex and/or nanoparticles such as previously defined. The invention finally relates to said complex and/or to said nanoparticles for the treatment and/or prevention of hyperlipemia and hypercholesterolemia.
La présente invention concerne un complexe formé d'au moins une molécule de statine ou dérivé, couplée de manière covalente à au moins un radical hydrocarboné comprenant au moins 18 atomes de carbone et contenant au moins une unité 2-méthyl- buta-2-ène, des nanoparticules d'un tel complexe et leur procédé de préparation, ledit complexe et/ou lesdites nanoparticules étant éventuellement sous forme de lyophilisât. La présente invention vise aussi une composition pharmaceutique comprenant au moins un complexe et/ou des nanoparticules tels que définis précédemment. Elle vise enfin ledit complexe et/ou lesdites nanoparticules pour le traitement et/ou la prévention d'hyperlipémie, d'hypercholestérolémie.
Couvreur Patrick
Desmaele Didier
Lakkireddy Harivardhan Reddy
Zouhiri Fatima
Centre National de La Recherche Scientifique
Robic
Universite Paris Sud
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