Statine-derived tetrapeptide inhibitors of beta-secretase

Details Statine-derived tetrapeptide inhibitors of beta-secretase Statine-derived tetrapeptide inhibitors of beta-secretase

C - Chemistry, Metallurgy

07

K

C07K 5/02 (2006.01) A61K 38/05 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2376420

Statine-derived peptide inhibitors of the .beta.-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A.beta. peptide in a mammal. The compounds of the invention provide useful methods of treatment by administration of these inhibitors to reduce A.beta. peptide formation and pharmaceutical compositions.

L'invention concerne les inhibiteurs peptides dérivés de la statine de l'enzyme .beta.-secretase qui sont utilisés pour traiter la maladie d'Alzheimer ainsi que d'autres maladies caractérisées par le dépôt de peptide A.beta. chez un mammifère. Les composés de cette invention procurent des procédés de traitement utiles par administration de ces inhibiteurs et de compositions pharmaceutiques afin de réduire la formation de peptide A.beta..

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