Statins (hmg-coa reductase inhibitors) as a novel type of...

A - Human Necessities – 61 – K

Patent

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A61K 45/06 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2474201

The present invention relates to methods of causing MHC-class II or CD40 mediated immunomodulation, immunosuppression and anti-inflammatory action, in a subject suffering from or susceptible of suffering from a condition involving inappropriate immune response, which comprises administering to the subject at least one statin in an amount effective to modulate MHC class II or CD40 expression in the subject.

L'invention concerne des procédés servant à provoquer une action immunomodulatoire, immunosuppressive et anti-inflammatoire dans laquelle MHC de classe II ou CD40 joue un rôle médiateur chez un sujet atteint ou susceptible d'être atteint par un état impliquant une réponse immune inappropriée, ce qui consiste à administrer à ce sujet au moins une statine en quantité efficace pour moduler l'expression de MHC de classe II ou de CD40.

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