Stationary phase, stress response sigma factor from...

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C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/04 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/35 (2006.01) C07K 16/12 (2006.01) C07K 19/00 (2006.01) C12N 15/74 (2006.01) C12Q 1/02 (2006.01) C12Q 1/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/543 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2249208

sigF is a gene that controls M. tubercolusis latency. A diagnostic test for latent tuberculosis involves detecting M. tuberculosis sigF in clinical specimens. Two genes orfX and orfY regulate sigF expression and sigF activity. M. tuberculosis sigF, orfX and orfY are used in screening methods for potential therapeutic agents which regulate the growth of M. tuberculosis.

L'invention a trait au facteur sigma d'un gène (sigF), agissant sur la latence du Mycobacterium tuberculosis. Une épreuve diagnostique d'une tuberculose à l'état latent repose sur la détection de sigF du M. tuberculosis dans des spécimens cliniques. Deux gènes, orfX et orfY, régulent l'expression de sigF ainsi que son activité. On utilise sigF de M. tuberculosis ainsi que les gènes orfX et orfY dans des méthodes de criblage aux fins de la détection d'agents thérapeutiques potentiels susceptibles de réguler la croissance du M. tuberculosis.

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