Staurosporine derivatives for treating non-small cell lung...

Details Staurosporine derivatives for treating non-small cell lung... Staurosporine derivatives for treating non-small cell lung...

A - Human Necessities

61

K

A61K 31/553 (2006.01)

Patent

CA 2617898

The present invention relates to a method of treating non-small cell lung cancer with FLT-3 kinase inhibitor such as PKC412. The invention also relates to a pharmaceutical combination of a FLT-3 kinase inhibitor and an activator of permeablization of the mitochondrial outer membrane, such as an activator of BAK. It also relates to the use of a pharmaceutical combination of an activator of permeablization of the mitochondrial outer membrane and a FLT-3 kinase inhibitor for the treatment of non-small cell lung cancer and the use of such a pharmaceutical composition for the manufacture of a medicament for the treatment of same.

L'invention concerne une méthode de traitement d'un cancer bronchopulmonaire "non à petites cellules" à l'aide d'un inhibiteur de kinase FLT-3, notamment PKC412. L'invention concerne également une combinaison pharmaceutique d'un inhibiteur de kinase FLT-3 et d'un activateur de perméabilisation de la membrane extérieure mytochondriale, notamment un activateur de BAK. L'invention concerne également l'utilisation d'une combinaison pharmaceutique d'un activateur de perméabilisation de la membrane extérieure mytochondriale et d'un inhibiteur de kinase FLT-3, pour traiter un cancer bronchopulmonaire "non à petites cellules"; et l'utilisation d'une telle composition pharmaceutique pour fabriquer un médicament pour traiter le cancer susmentionné.

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