Staurosporine derivatives for use in alveolar rhabdomyosarcoma

Details Staurosporine derivatives for use in alveolar rhabdomyosarcoma Staurosporine derivatives for use in alveolar rhabdomyosarcoma

A - Human Necessities

61

K

A61K 31/553 (2006.01) A61K 31/4025 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2629478

This invention relates to staurosporine derivatives are effective when used in combination with ionizing radiation for the delay of progression or treatment of a proliferative disease, especially a disease associated with a PAX/FKHR translocation including a PAX3/FKHR translocation and a PAX7/FKHR translocation, more especially a solid tumor disease such as a Sarcoma, most especially an Alveolar Rhabdomyosarcoma.

La présente invention concerne des dérivés de la staurosporine qui, en combinaison avec des rayonnements ionisants, sont capables de retarder la progression d'une maladie proliférative ou de traiter une maladie proliférative, ladite maladie proliférative étant en particulier une maladie associée à une translocation PAX/FKHR y compris les translocations PAX3/FKHR et PAX7/FKHR, plus particulièrement une maladie à tumeur solide telle qu'un sarcome et tout particulièrement un rhabdomyosarcome alvéolaire.

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