Staurosporine derivatives with substituted methylamino nitrogen

Details Staurosporine derivatives with substituted methylamino nitrogen Staurosporine derivatives with substituted methylamino nitrogen

C - Chemistry, Metallurgy

07

D

167/209, 260/238

C07D 498/18 (2006.01) A61K 31/55 (2006.01) C07D 498/22 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 1337763

N-substituted derivatives of staurosporine of the general formula [Stau]-N(CH3)-R (I) in which [Stau] represents a residue of the partial formula Image [Stau] and R represents a hydrocarbyl radical Ro or an acyl radical Ac, which radicals preferably have a maximum of 30 carbon atoms, and salts of compounds of the formula I having salt-forming properties, are distinguished as selective inhibitors of proteinkinase C. They are manufactured by conventional alkylation or acylation, respectively, of staurosporine.

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