A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/51 (2006.01)
Patent
CA 2488385
The present invention relates to stealth lipid nanocapsules consisting of an essentially lipid core which is liquid or semi-liquid at ambient temperature, and an outer lipid envelope comprising at least one hydrophilic surfactant which is lipidic in nature, at least one lipophilic surfactant which is lipidic in nature and at least one amphiphilic derivative of poly(ethylene glycol), the molar mass of the poly(ethylene glycol) component of which is greater than or equal to 1 000 g/mol, preferably greater than or equal to 2 000 g/mol, to the methods for the preparation thereof and to the use thereof as a carrier for active principle(s).
L'invention concerne des nanocapsules lipidiques indétectables consistant en un noyau essentiellement lipidique qui est liquide ou semi-liquide à température ambiante, et une enveloppe lipidique externe comprenant au moins un tensio-actif hydrophile de nature lipidique, au moins un tensio-actif lipophile de nature lipide et au moins un dérivé amphiphile de poly(éthylène glycol), dont la masse molaire du composant de poly(éthylène glycol) est supérieure ou égale à 1 000 g/mol, et de préférence supérieure ou égale à 2 000 g/mol. L'invention concerne également des procédés de préparation de ces nanocapsules et leur utilisation en tant que support de principe(s) actif(s).
Delmas Pascal
Hoarau Didier
Leroux Jean-Christophe
Ethypharm
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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