Stealth virus nucleic acids and related methods

Details Stealth virus nucleic acids and related methods Stealth virus nucleic acids and related methods

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07K 14/03 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2282858

Stealth viruses comprise a molecularly heterogeneous grouping of atypically structured, vacuolating cytopathic viruses, that cause persistent systemic infection, often with neuropsychiatric and potentially with oncogenic and auto- immune manifestations, in the absence of significant anti-viral inflammation. The appearance, progression and host range characteristics of the cytopathic effect (CPE) distinguish stealth viruses from conventional human cytopathic viruses, including herpesviruses, enteroviruses and adenoviruses. Electron microscopy, serology and molecular-based assays can be used to further differentiate stealth viruses from conventional viruses. Stealth viruses can assimilate various cellular-derived and bacteria-derived genes and potentially transfer such genes between individuals or similar or even differing species. This application describes methods for detecting stealth viruses using molecular probes and for determining the composition of individual stealth virus isolates, based on the DNA and/or RNA nucleotide sequences detectable in cultures and in clinical and other materials containing a stealth virus.

Les virus discrets comprennent un groupement hétérogène du point de vue moléculaire, de virus cytopathologiques vacuolants, à structure atypique, induisant une infection systémique persistante, accompagnée souvent de manifestations neuropsychiatriques et éventuellement oncogènes et auto-immunes, en l'absence d'inflammation antivirale manifeste. L'apparition, la progression et les spectres d'activités caractéristiques de l'effet cytopathologique (CPE) distinguent les virus discrets des virus cytopathologiques humains classiques, dont les herpèsvirus, les entérovirus et les adénovirus. On peut utiliser la microscopie électronique, la sérologie et d'autres analyses moléculaires pour encore distinguer les virus discrets des virus classiques. Lesdits virus discrets peuvent assimiler divers gènes dérivés de cellules et dévirés de bactéries et éventuellement transférer lesdits gènes entre individus ou similaires, voire même entre différentes espèces. L'invention concerne des procédés de détection de virus discrets, au moyen de sondes moléculaires et de détermination de la composition d'isolats de virus discrets, en fonction des séquences nucléotidiques d'ADN et/ou d'ARN, détectables dans des cultures et dans des matériels cliniques ou autres, contenant un virus discret.

Affiliated with

Also associated with

Rating

Stealth virus nucleic acids and related methods does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Stealth virus nucleic acids and related methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stealth virus nucleic acids and related methods will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1589438