Stem cell differentiation

Details Stem cell differentiation Stem cell differentiation

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 31/7105 (2006.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01) C12N 5/02 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12P 19/34 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2456008

The invention relates to a method to modulate stem cell differentiation comprising introducing inhibitory RNA (RNAi) into a stem cell to ablate mRNA's which encode polypeptides which are involved in stem cell differentiation; RNAi molecules, DNA molecules encoding said RNAi molecules; and cells obtained by said method.

L'invention concerne un procédé de modulation de la différenciation de cellule ES consistant à introduire l'ARN inhibiteur (ARNi) dans une cellule ES afin de réaliser l'ablation des ARNm qui codent des polypeptides prenant part à la différenciation de cellule ES; de molécules ARNi, de molécules d'ADN codant lesdites molécules ARNi et enfin, de cellules obtenues au moyen dudit procédé.

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