Stem cell fusion model of carcinogenesis

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) C12N 5/16 (2006.01) C12N 15/02 (2006.01) C12Q 1/02 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2620616

Methods for modeling cancer cell migration, screening drugs for effects on tumor cell migration, and detecting the potential for tumor cell migration relating to the fusion of a bone marrow derived stem cell with a genetically altered cell (Fig. 1). Antibodies against ubiquitin are shown to inhibit tumor cell migration.

L'invention concerne des procédés pour modéliser la migration de cellules cancéreuses, cribler des médicaments destinés à agir sur la migration de cellules tumorales, et détecter le potentiel de migration de cellules tumorales en rapport avec la fusion d'une cellule souche de moelle osseuse avec une cellule génétiquement modifiée. Il a été démontré que les anticorps dirigés contre l'ubiquitine inhibent la migration de cellules tumorales.

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