Stem cell inhibiting proteins

Details Stem cell inhibiting proteins Stem cell inhibiting proteins

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 38/19 (2006.01) C07K 14/52 (2006.01) C12N 1/19 (2006.01) C12N 15/67 (2006.01) C12N 15/81 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2125985

Proteinaceous molecules with stem cell inhibition activity are analogues of LD78 or MIP-1.alpha. which have mutations to prevent or reduce multimer formation beyond certain stages (for example a dodecamer). Aggregate formation is therefore inhibited, and the resulting low molecular weight monomers (or oligomers) have improved solution properties leading to enhanced productivity and greater therapeutic utility as stem cell protective agents, which are useful in tumour therapy.

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