Stem cell proliferation factor

Details Stem cell proliferation factor Stem cell proliferation factor

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 39/39 (2006.01) A61K 49/00 (2006.01) C07K 14/475 (2006.01) C07K 14/52 (2006.01) C07K 14/53 (2006.01) C07K 14/535 (2006.01) C07K 14/705 (2006.01) C07K 16/22 (2006.01) C07K 16/24 (2006.01) C12N 5/02 (2006.01) C12N 15/19 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2133646

The present invention is directed to an autocrine growth factor isolated from a human germ cell tumor line. In particular, it relates to the production, purification and uses of stem cell proliferation factor (SCPF). The protein of the invention exists in two foams, a soluble form and a membrane bound form which is detectable on the surface of a small percentage of human. bane mar- row cells and stimulates the proliferation of these cells. Therefore, SCPF may have a wide range of applications including but not limited to augmenting the growth of hematopoietic stem cells. Further, removal of the protein by an antibody may be useful in controlling tumor cell growth.

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