C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) A61K 31/70 (2006.01) A61K 47/48 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2215825
The present invention provides stem-loop and circular oligonucleotides each with at least one Watson-Crick binding (WC) domain and at least one corresponding Hoogsteen binding (H) domain separated from each other by linker domains. Each WC domain has sufficient complementarity to bind to one strand of a defined nucleic acid target by Watson-Crick base pairing in an anti- parallel orientation. Each corresponding H domain is capable of binding to the WC domain by Hoogsteen base pairing in an anti-parallel manner. The present invention also provides methods of making and using these oligonucleotides as well as kits and pharmaceutical compositions containing these oligonucleotides.
L'invention concerne des oligonucléotides à tige/boucle et circulaires comprenant chacun un domaine de liaison de Watson Crick (WC) et au moins un domaine de liaison de Hoogsteen (H) correspondant, ces derniers étant séparés l'un de l'autre par des domaines de liaison. Chaque domaine WC présente une complémentarité suffisante pour se lier à un brin d'acide nucléique cible défini, par appariement de bases de Watson Crick selon une orientation antiparallèle. Chaque domaine H correspondant est capable de se lier au domaine WC par appariement de bases de Hoogsteen selon une configuration antiparallèle. L'invention concerne également des procédés de préparation et d'utilisation de ces oligonucléotides ainsi que des trousses et des compositions pharmaceutiques contenant ces derniers.
Mcfadden Fincham
Research Corporation Technologies Inc.
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