Stent coatings containing hmg-coa reductase inhibitors

Details Stent coatings containing hmg-coa reductase inhibitors Stent coatings containing hmg-coa reductase inhibitors

A - Human Necessities

61

L

A61L 31/16 (2006.01)

Patent

CA 2464329

Stents with coatings comprising a combination of a restenosis inhibitor comprising an HMG-CoA reductase inhibitor and a carrier. Also provided are methods of coating stents with a combination of an HMG-CoA reductase inhibitor and a carrier. A preferred example of a restenosis inhibitor is cerivastatin. The stent coatings have been shown to release restenosis inhibitors in their active forms.

La présente invention concerne des stents avec des revêtements comprenant une combinaison d'un inhibiteur de resténose comprenant un inhibiteur de réductase HMG-CoA et un porteur. Cette invention concerne aussi des procédés de revêtement de stents avec une combinaison d'inhibiteur de réductase HMG-CoG et d'un porteur. Un exemple préféré d'inhibiteur de resténose est la cérivastatine. On a constaté que ces revêtements de stent libéraient des inhibiteurs de resténose dans leurs formes actives.

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