Stereocontrolled production of hydroxyester, hydroxyamide,...

Details Stereocontrolled production of hydroxyester, hydroxyamide,... Stereocontrolled production of hydroxyester, hydroxyamide,...

C - Chemistry, Metallurgy

07

D

C07D 307/33 (2006.01) C07C 271/22 (2006.01) C07D 263/52 (2006.01) C07D 413/12 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2057369

75/GHB17 18259 TITLE OF THE INVENTION STEREOCONTROLLED PRODUCTION OF HYDROXYESTER, HYDROXYAMIDE AND LACTONE COMPOUNDS FROM CHIRAL .alpha.-AMINO ALDEHYDES ABSTRACT OF THE DISCLOSURE A process for stereocontrolled preparation of a medicinally significant hydroxyester, hydroxyamide or lactone compound of structural formula: Image comprises the addition of homoenolate equivalents to chiral .alpha.-amino aldehydes. The hydroxyester, hydroxyamide, or lactone reaction products arc useful as inhibitors of the HIV protease or of renin, or as intermediates in the preparation of inhibitors of the HIV protease or renin.

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