C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 41/00 (2006.01) C07C 315/06 (2006.01) C07C 319/28 (2006.01) C12P 7/24 (2006.01) C12P 11/00 (2006.01) C12P 13/04 (2006.01) C07C 317/48 (2006.01) C07C 323/63 (2006.01)
Patent
CA 2064349
Mixtures of enantiomeric D,L-threo 2-amino-3-hydroxy-3- phenylpropionic acids can be stereoisomerically enriched by contacting the mixture with a D-threonine aldolase. In a typical embodiment, D- and L-threo 2-amino-3-hydroxy-3-(4- methylsulfonylphenyl)propionic acid is treated with D-threo- nine aldolase to produce L-threo 2-amino-3-hydroxy-3-(4- methylsulfonylphenyl)propionic acid with a high ee. The benzaldehyde and amino acid formed from the D-threo isomer can be recycled.
Raju Muppala S.
Stirling David I.
Zeitlin Andrew L.
Celgene Corporation
Gowling Lafleur Henderson Llp
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