C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 13/00 (2006.01) C12P 7/40 (2006.01)
Patent
CA 2563307
The present invention is directed to a regio-and stereoselective bioconversion of selected aliphatic dinitriles into corresponding cyanocarboxylic acids. More particularly, the present invention provides methods for the conversion of 2-isobutyl-succinonitrile into (S)-3~ cyano-5-methylhexanoic .acid, which is a useful intermediate in the synthesis of (S)-3~(aminomethyl)-5- methylhexanoic acid (pregabalin). Pregabalin can be used for treating certain cerebral diseases, for example, in the treatment and prevention of seizure disorders, pain, and psychotic disorders.
L'invention concerne la bioconversion régiosélective et stéréosélective de dinitriles aliphatiques sélectionnés en acides cyanocarboxyliques correspondants. Cette invention concerne de manière plus spécifique des procédés pour convertir le composé 2-isobutyl-succinonitrile en acide (S)-3-cyano-5-méthylhexanoïque, qui constitue un intermédiaire utile dans la synthèse de l'acide (S)-3-(aminométhyl)-5-méthylhexanoïque (prégabaline). La prégabaline peut être utilisée pour traiter certaines maladies cérébrales, par exemple elle peut servir à traiter et prévenir les troubles épileptiques, la douleur, et les troubles psychotiques.
Burns Michael Paul
Weaver Justin Kaine
Wong John Wing
Pfizer Products Inc.
Smart & Biggar
LandOfFree
Stereoselective bioconversion of aliphatic dinitriles into... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Stereoselective bioconversion of aliphatic dinitriles into..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stereoselective bioconversion of aliphatic dinitriles into... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1877595