Stereoselective microbial or enzymatic reduction of...

C - Chemistry – Metallurgy – 12 – P

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C12P 17/16 (2006.01) C07D 319/06 (2006.01) C07D 405/06 (2006.01) C12P 7/62 (2006.01) C12P 17/06 (2006.01)

Patent

CA 2094191

Microorganisms or reductases derived therefrom reduce a diketo ester (see formula I) to form the associated 3-hydroxy, 5-hydroxy, or 3,5-dihydroxy esters. Selected microorganisms produce the preferred stereoisomers (see formula II, III, IV) which can be used to prepare antihypercholesterolemic agents such as (see formula V)

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