Stereoselective microbial reduction of a racemic tetralone

Details Stereoselective microbial reduction of a racemic tetralone Stereoselective microbial reduction of a racemic tetralone

C - Chemistry, Metallurgy

12

P

C12P 7/22 (2006.01) C12P 7/26 (2006.01) C12P 41/00 (2006.01)

Patent

CA 2287560

The present invention relates to processes for carrying out the following stereoselective microbial reduction of a racemic tetralone: (see formula I) which comprises: contacting a compound of formula (I) with a microorganism, or an enzyme reduction system capable of accomplishing the subject reduction comprising an enzyme derived from said microorganism and a co-factor for said enzyme, and incubating the resulting mixture under conditions sufficient to yield the (4R) tetralol of formula (II) and to leave substantially unreacted the (4S) tetralone of formula (V) or "chiral tetralone." The chiral tetralone can be used in the synthesis of sertraline. The subject process further optionally comprises the separation of the (4S) tetralone of formula (V) from the (4R) tetralol of formula (II). The (4R) tetralol can be recycled to produce the compound of formula (I) and the subject process repeated to result in even more of the desired (4S) tetralone of formula (V).

Affiliated with

Also associated with

Rating

Stereoselective microbial reduction of a racemic tetralone does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Stereoselective microbial reduction of a racemic tetralone, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stereoselective microbial reduction of a racemic tetralone will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2012884