Stereoselective preparation of 2-substituted succinic...

C - Chemistry – Metallurgy – 12 – P

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C12P 41/00 (2006.01) C07C 19/01 (2006.01) C07C 19/075 (2006.01) C07C 69/65 (2006.01) C07C 233/09 (2006.01) C07C 235/76 (2006.01) C07D 213/40 (2006.01) C07D 213/56 (2006.01) C07D 213/75 (2006.01) C07D 277/20 (2006.01) C07D 277/38 (2006.01) C07D 277/40 (2006.01) C07D 277/48 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2165996

A highly efficient and practical means has been developed which enables compounds of the formula: Image wherein R1 is lower alkoxy, lower alkylamino, di- (loweralkyl)amino, or the monovalent radical A-NR3, wherein A is lower alkyl or A is R4R5NC(O)CH2 wherein, for example, R4 is hydrogen or alkyl and R5 is hydrogen, alkyl or a substituted alkyl, or R5 is R6R7N-Alk wherein R6 and R7 each is hydrogen or lower alkyl and Alk is a divalent alkyl radical; R3 is, for example, benzyl, alkyl or a substituted alkyl; and R2 is, inter alia, alkyl, cycloalkyl, 1H- imidazol-4-yl, 4-thiazolyl or 2-amino-4-thiazolyl; to be prepared through the kinetic resolution of a compound of the formula: Image wherein R1 is as defined herein, R2 is as defined herein, and B is lower alkyl. These compounds are useful intermediates in the synthesis of renin inhibiting compounds.

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