Stereoselective preparation of halophenyl alcohols

C - Chemistry – Metallurgy – 12 – P

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C12P 7/22 (2006.01) C12P 17/12 (2006.01) C12P 17/16 (2006.01)

Patent

CA 2081069

HA583 ABSTRACT STEREOSELECTIVE PREPARATION OF HALOPHENYL ALCOHOLS A process is described for selectively preparing a compound of the formula Image wherein: R1 is halogen; R2 is halogen, alkyl, cycloalkyl, aryl or Image ; and R3 is hydrogen, alkyl, cycloalkyl, aryl, or Image halogen; wherein the process comprises treating the associated ketone with an oxido-reductase or a microorganism comprising an oxidoreductase. Compounds prepared by this process are useful antipsychotic agents or useful intermediates therefor.

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