Stereoselective reduction of ketones

Details Stereoselective reduction of ketones Stereoselective reduction of ketones

C - Chemistry, Metallurgy

12

P

C12P 41/00 (2006.01) C07C 311/08 (2006.01) C07C 311/21 (2006.01) C12P 13/02 (2006.01)

Patent

CA 2103932

ABSTRACT OF THE DISCLOSURE The present invention concerns a process for the stereoselective enzymatic reduction of keto group-containing compounds such as N-(4-(2-chloroacetyl)phenyl)methanesulfon- amido to form the corresponding hydroxyl-group containing compound. The process is selective for the D(+) enantiomer and is catalyzed by enzymes such as oxido-reductase or dehydrogense, or by microorganisms such as Hansenula, Rhodococcus, or Norcardia species.

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