C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 41/00 (2006.01) C12P 7/22 (2006.01)
Patent
CA 2441267
The present invention is directed to novel stereoselective processes for the preparation of (S)-1-arylethanols by the reduction of the corresponding keto group containing compounds by microorganisms. (S)-1-arylethanols are useful as intermediates in the synthesis of compounds that are inhibitors of .gamma.- secretase useful in the treatment of Alzheimer's disease.
La présente invention concerne des procédés stéréosélectifs pour la préparation de (S)-1-aryléthanols par réduction de composés renfermant le groupe cétone correspondant au moyen de micro-organismes. Les (S)-1-aryléthanols sont utiles en tant qu'intermédiaires pour la synthèse de composés qui sont des inhibiteurs de la .gamma.-sécrétase utilisée dans le traitement de la maladie d'Alzheimer.
Chu Linda
Donovan Mary Jo
Goldberg Steven
Goswami Animesh
Johnston Robert
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
LandOfFree
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