Stereospecific anxiolytic and anticonvulsant agents with...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 243/16 (2006.01) A61K 31/5517 (2006.01) A61P 25/22 (2006.01) C07D 243/24 (2006.01) C07D 487/04 (2006.01) C07D 495/04 (2006.01) C07D 495/14 (2006.01)

Patent

CA 2570185

The present invention provides compositions and methods of using stereospecific benzodiazepine derivatives, their salts and prodrugs for the treatment of anxiolytic or convulsant disorders having the side effects of reduced alcohol craving in human alcoholics and a concomitant reduced sedative, hypnotic, muscle relaxant and ataxic side-effects. The invention further provides pharmaceutical compositions for treatment of anxiolytic and convulsant disorders in subjects in need thereof, comprising a compound, prodrug or a salt having a chemical structure represented by any one of Formula I-XXI and a pharmaceutically-acceptable carrier.

L'invention concerne des compositions et des procédés pour utiliser des dérivés de benzodiazépine stéréospécifiques, leurs sels et leurs promédicaments pour traiter des troubles anxieux et convulsifs, lesdits dérivés ayant pour effet secondaire de réduire le besoin d'alcool chez des alcooliques humains et présentant concomitamment des effets indésirables de type sédatifs, hypnotiques, myorelaxants et ataxiques réduits. Cette invention concerne également des compositions pharmaceutiques pour traiter des troubles anxieux et convulsifs chez des sujets en ayant besoin, ces compositions comprenant un composé, un promédicament ou un sel présentant une structure chimique représentée par une quelconque des formules (I-XXI) et un excipient pharmaceutiquement acceptable.

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