Sterically hindered derivatives of water soluble polymers

Details Sterically hindered derivatives of water soluble polymers Sterically hindered derivatives of water soluble polymers

C - Chemistry, Metallurgy

08

G

C08G 65/332 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2394980

The invention provides a sterically hindered polymer that comprises a water- soluble and non-peptidic polymer back-bone having at least one terminus covalently bonded to an alkanoic acid or alkanoic acid derivative, wherein the carbon adjacent to the carbonyl group of the acid or acid derivative group has an alkyl or aryl group pendent thereto. The steric effects of the alkyl or aryl group allow greater control of the hydrolytic stability of polymer derivatives. The polymer backbone may be poly(ethylene glycol).

Cette invention se rapporte à un polymère à empêchement stérique, qui comprend un squelette polymère hydrosoluble et non peptidique ayant au moins une terminaison liée par covalence à un acide alcanoïque ou à un dérivé d'acide alcanoïque, le carbone adjacent au groupe carbonyle du groupe acide ou du groupe du dérivé acide comportant un groupe alkyle ou aryle pendant. Les effets stériques du groupe alkyle ou aryle permettent une meilleure régulation de la stabilité hydrolytique des dérivés polymères. Le squelette polymère peut être du poly(éthylène glycol).

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