Sterile complex of therapeutic peptide bond to a polysaccharide

Details Sterile complex of therapeutic peptide bond to a polysaccharide Sterile complex of therapeutic peptide bond to a polysaccharide

A - Human Necessities

61

L

A61L 15/28 (2006.01) A61L 15/22 (2006.01) A61L 15/32 (2006.01) A61L 15/44 (2006.01) A61L 31/00 (2006.01) A61L 31/04 (2006.01)

Patent

CA 2319327

The invention provides sterile compositions comprising a complex of a therapeutic peptide and a polysaccharide selected from the group consisting of cellulose derivatives, chitin, chitosans, galactomannans, and mixtures thereof, wherein the complex has been sterilised with ionising radiation. The presence of the polysaccharides surprisingly stabilizes therapeutic peptides against decomposition under ionising conditions, especially under gamma- irradiation. Processes for the preparation of the sterile compositions and processes for the preparation of sterile therapeutic peptides are also claimed.

L'invention concerne des compositions stériles comprenant un complexe de peptide thérapeutique, et un polysaccharide sélectionné dans le groupe constitué par un dérivé de cellulose, une chitine, des chitosanes, des galactomannanes, et des mélanges de ceux-ci, ledit complexe ayant été stérilisé à l'aide d'un rayonnement ionisant. La présence des polysaccharides stabilise, de manière étonnante, les peptides thérapeutiques contre la décomposition, à l'aide de rayonnements ionisants, en particulier une irradiation Gamma. L'invention concerne également les techniques de préparation de ces peptides thérapeutiques.

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