Sterile preparations of phospholipids and anti-inflammatory...

A - Human Necessities – 61 – K

Patent

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A61K 9/127 (2006.01)

Patent

CA 2534234

A filter sterilized composition of a phospholipid and an anti-inflammatory pharmaceutical is disclosed, where the anti-inflammatory pharmaceutical is a nonsteroidal, anti-inflammatory drug (NSAID), a cyclooxygenase 2 (COX-2) inhibitor or a mixture thereof. A method for preparing these sterile compositions is also disclosed and includes a filtration step through a sterilizing filtration membrane. Methods for using these sterilized compositions to treat accident and battle field injuries or treatment of injuries to the nerve system especially in unconscious patients via injection, topical administration, or according to an administration protocol.

L'invention a trait à une composition stérilisée par filtration, qui contient un phospholipide et un médicament anti-inflammatoire, ledit médicament anti-inflammatoire étant un médicament anti-inflammatoire non stéroïdien (AINS), un inhibiteur de la cyclooxygénase 2 (COX-2) ou un mélange de ces derniers. L'invention se rapporte également à un procédé permettant de préparer lesdites compositions stériles, qui comprend une étape de filtration, effectuée à travers une membrane de filtration stérilisante. L'invention concerne aussi des procédés d'utilisation desdites compositions stérilisées pour traiter des blessures infligées lors d'accidents ou sur des champs de bataille, ou pour traiter des blessures infligées au système nerveux, en particulier chez des patients inconscients, par injection, administration topique ou conformément à un protocole d'administration.

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