Steroid analogues for neuroprotection

Details Steroid analogues for neuroprotection Steroid analogues for neuroprotection

C - Chemistry, Metallurgy

07

J

C07J 9/00 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2716095

Provided are steroid analogues functionalized with polar substituents at the C3 and/or C20 positions of the steroid ring system that exhibit improved water solubility. Also provided are pharmaceutical compositions comprising the steroid ana-logues and methods using the novel steroid analogues for the treatment and prevention of neurodegeneration in a patient following injury to the central nervous system.

Cette invention concerne des analogues stéroïdiens fonctionnalisés avec des substituants polaires en position C3 et/ou C20 du cycle stéroïdien, lesdits analogues présentant une meilleure solubilité dans leau. Linvention concerne également des compositions pharmaceutiques comprenant ces analogues stéroïdiens et des méthodes dutilisation de ces nouveaux analogues stéroïdiens dans le traitement et la prévention de la neurodégénérescence chez un patient après lésion du système nerveux central.

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