Steroid conjugates, preparation thereof and the use thereof

Details Steroid conjugates, preparation thereof and the use thereof Steroid conjugates, preparation thereof and the use thereof

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2492297

Conjugates comprising one or more steroids conjugated with one or more mammalian proteins are disclosed. The conjugates are useful for diagnosis or treatment of solid cancer and haematological malignancies. Further the conjugates exhibits a synergistic action together with a cytoskeleton acting drug such as Taxol~, which enable the treatment of cancers that otherwise would be non responsive to Taxol~.

L'invention concerne des conjugués comprenant un ou plusieurs stéroïdes conjugués avec une ou plusieurs protéines de mammifères. Les conjugués sont utilisés pour diagnostiquer ou traiter un cancer solide et des malignités hématologiques. Les conjugués font preuve, en outre, d'un effet synergistique doublé d'un effet sur le cytosquelette assuré par un médicament, notamment le Taxol, permettant le traitement de cancers qui ne réagiraient pas, autrement, au Taxol·.

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