Steroid derivatives and their use in radioimmunoassays

Details Steroid derivatives and their use in radioimmunoassays Steroid derivatives and their use in radioimmunoassays

C - Chemistry, Metallurgy

07

J

260/28.2

C07J 1/00 (2006.01) C07J 5/00 (2006.01) C07J 7/00 (2006.01) C07J 21/00 (2006.01) G01N 33/60 (2006.01)

Patent

CA 1142915

RB53 ABSTRACT STEROID DERIVATIVES AND THEIR USE IN RADIOIMMUNOASSAYS Radiolabeled Steroid derivatives having the formula Image wherein St is a 6-dehydro derivative of a 3-oxo-4,5- dehydro steroid intended for radioimmunoassay, said steroid being saturated in the 1,2-position; R is hydrogen or alkyl of 1 to 3 carbon atoms; n is 0, 1, 2, 3 or 4; and the asterisk (*) indicates tagging with a radioisotope, are useful as tracers in radioimmuno- assays. The unlabeled analogs can be coupled with an immonogenic carrier and used to induce antibody formation in animals.

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