Steroid derivatives and use thereof as medicaments

Details Steroid derivatives and use thereof as medicaments Steroid derivatives and use thereof as medicaments

C - Chemistry, Metallurgy

07

J

C07J 61/00 (2006.01) A61K 31/56 (2006.01)

Patent

CA 2536486

The invention concerns the field of chemistry and, more particularly, the field of organic chemistry. The invention specifically relates to novel A-nor steroids according to general formula (I) in which R represents hydrogen, a lower alkyl radical having 1 to 7 carbon atoms, a lower cycloalkyl radical having 3 to 7 carbon atoms, an aryl radical having 5 to 10 carbon atoms, an arylalkyl radical in which the alkyl group has 1 to 6 carbon atoms, or an acyl radical derived from an aliphatic carboxylic acid, from a cycloalkyl carboxylic acid or from an aryl carboxylic acid. The invention also relates to pharmaceutical compositions containing, as an active substance, at least one compound of general formula (I) in association or mixed with an excipient or an appropriate vehicle. The inventive pharmaceutical compositions can also contain another active substance that having a similar or synergetic action. The compounds of general formula (I) are used as medicaments that aid in fixing calcium by osteoblasts.

La présente invention se rapporte au domaine de la chimie et plus particulièrement à celui de la chimie organique. Elle a spécifiquement pour objet de nouveaux A-nor stéroïdes répondant à la formule générale (I) dans laquelle R est de l'hydrogène, un radical alcoyle inférieur ayant de 1 à 7 atomes de carbone, un radical cycloalcoyle inférieur ayant de 3 à 7 atomes de carbone, un radical aryle ayant de 5 à 10 atomes de carbone, un radical arylalcoyle où le groupe alcoyle a de 1 à 6 atomes de carbone, ou un radical acyle dérivé d'un acide aliphatique carboxylique, d'un acide cycloalcoylcarboxylique ou d'un acide arylcarboxylique. L'invention a encore pour objet les compositions pharmaceutiques renfermant, à titre de principe actif , au moins un composé de la formule générale (I) en association ou en mélange avec une excipient ou un véhicule approprié. Les compositions pharmaceutiques selon l'invention peuvent en outre contenir un autre principe actif d'action similaire ou synergique. Utilisation des composés de formule générale (I) comme médicaments pour favoriser la fixation du calcium parles ostéoblastes.

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