Steroid derivatives for the treatment of prostatic...

Details Steroid derivatives for the treatment of prostatic... Steroid derivatives for the treatment of prostatic...

C - Chemistry, Metallurgy

07

J

C07J 41/00 (2006.01) A61K 31/56 (2006.01) C07J 43/00 (2006.01)

Patent

CA 2094300

Compounds of formula (I): (see formula I) [wherein: R1 is hydrogen, alkyl, aryl-substituted alkyl or aromatic heterocyclic-substituted alkyl; R2 is: aryl-substituted alkyl, aromatic heterocyclic- substituted alkyl or diarylamino; and R3 is carboxy or a group of formula -CONHSO2R4 wherein R4 is alkyl]; and pharmaceutically acceptable salts and esters thereof have valuable 5.alpha.-reductase inhibitory activity and can thus be used for the treatment and prophylaxis of, inter alia, prostatic hypertrophy as well as other disorders arising from excess levels of 5.alpha.-dihydro- testosterone.

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