C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
260/15, 167/196
C07J 71/00 (2006.01) A61K 31/57 (2006.01) C07J 7/00 (2006.01)
Patent
CA 2011280
NOVEL STEROID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCES FOR PREPARING SAME A b s t r a c t The invention relates to novel .DELTA.14-16.alpha.,17-dihydroxy- pregnane-16,17-cyclic aldehyde acetal and -cyclic ketone ketal derivatives of general formula (I), Image (I) wherein A stands for hydrogen or hydroxyl group; X stands for hydrogen or halogen with the proviso that if A is hydrogen, then X also means hydrogen; R stands for hydrogen,benzoyl or C1-8alkanoyl group; R1 and R2, which are the same or different, stand for hydrogen or a C1-4alkyl group; or one of R1 and R2 is hydrogen and the other is phenyl group; or R1 and R2 together form a C4-5alkylene group; Image means a single or double bond between two adjacent carbon atoms, as well as pharmaceutical compositions containing these compounds and a process for their preparation. The compounds of general formula (I) possess a very strong antiinflammatory effect and only week harmful side effect. Thus, they can be used as active ingredients of antiinflammatory pharmaceutical compositions being useful in the therapy.
Boor Anna
Csorgei Janos
Fekete Gyorgy
Forgacs Lilla
Hajos Gyorgy
Fetherstonhaugh & Co.
Richter Gedeon Vegyeszeti Gyar Rt
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