A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/10 (2006.01)
Patent
CA 2588433
The invention provides steroid-containing pharmaceutical compositions which are free of classical preservatives and preferably comprise a steroid that is sparingly soluble or substantially insoluble in water, particulate steroid having an average particle size of from about 2.2 to about 10 microns. Pharmaceutical compositions consisting essentially of particulate triamcinolone acetonide, methylcellulose or hydroxy(C1- C8)alkylmethylcellulose, an pharmaceutically acceptable salt, and water are provided by the invention, which compositions are substantially free of non- saccharide polymers and preservatives. The pharmaceutical compositions can be used to treat medical conditions, including ophthalmological conditions and pain.
La présente invention concerne des compositions pharmaceutiques contenant un stéroïde, qui sont exemptes de conservateurs classiques et comprennent de préférence un stéroïde qui est modérément soluble ou sensiblement insoluble dans l'eau, un stéroïde particulaire présentant une taille particulaire d'environ 2,2 à environ 10 microns. Ces compositions pharmaceutiques sont principalement constituées d'acétonide de triamcinolone particulaire, de méthylcellulose ou d'hydroxy(C1-C8)alkylméthylcellulose, d'un sel acceptable d'un point de vue pharmaceutique et d'eau. Lesdites compositions sont essentiellement exemptes de polymères non saccharides et de conservateurs et peuvent être utilisées pour traiter des pathologies médicales, en particulier des pathologies et des douleurs ophtalmiques.
Csaky Karl G.
Gravlin Luisa V.
Grimes George
Potti Gopal K.
Robinson Michael R.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Government Of The United States Of America As Represented By The
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