A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/567 (2006.01) A61K 9/16 (2006.01) A61K 31/565 (2006.01) A61K 31/569 (2006.01) A61K 31/57 (2006.01) A61K 47/26 (2006.01) A61P 5/30 (2006.01)
Patent
CA 2431521
The present invention relates to steroid hormone products, such as oral contraceptive products, including at least one steroid active ingredient mixed with an excipient and having improved dissolution and release rate properties. The invention further relates to methods for making such steroid hormone products, wherein a mixture of the hormone and the excipient is subjected to sufficient mechanical energy to form a powder blend wherein the hormone is stabilized by the excipient in substantially non-crystalline form.
La présente invention concerne des produits à base d'hormones stéroïdes, tels que des produits contraceptifs oraux, comprenant au moins un ingrédient stéroïdien actif mélangé à un excipient et présentant des caractéristiques de dissolution et de libération améliorées. Cette invention concerne également des procédés de fabrication desdits produits consistant à soumettre le mélange d'hormone et d'excipient à une énergie mécanique suffisante pour former un mélange en poudre dans lequel l'hormone es stabilisée par l'excipient sous une forme sensiblement non cristalline.
Clark Bradley A.
Falzone Angela
Schultz Thomas
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Ortho-Mcneil Pharmaceutical Inc.
Ortho-Mcneil-Janssen Pharmaceuticals Inc.
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