Steroid ointment formulation

Details Steroid ointment formulation Steroid ointment formulation

A - Human Necessities

61

K

167/159, 167/192

A61K 31/565 (2006.01) A61K 9/06 (2006.01) A61K 47/00 (2006.01)

Patent

CA 1326448

STEROID OINTMENT FORMULATION Abstract A steroid ointment formulation which has enhanced physical and chemical stability is formed of (11.beta.,17.alpha.)-17-(ethylthio)-9.alpha.-fluoro-11.beta.-hydroxy- 17-(methylthio)androsta-1,4-dien-3-one (tipredane), and a vehicle containing as major ingredients propylene glycol and water, cetearyl alcohol and ceteareth 20 or other dispersing agent for propylene glycol, together with a sodium or potassium citrate and magnesium hydroxide buffer to impart a neutral or slightly alkaline apparent pH (5 to 9), a non-acidic long chain fatty acid wax to impart proper consistency to the ointment and sodium metabisulfite and butylated hydroxy toluene as antioxidants, together with thickeners, emollients, lubricants and other conventional ointment formulation ingredients.

579960

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