C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
195/19
C12P 33/16 (2006.01) C07J 9/00 (2006.01) C12N 15/01 (2006.01) C12P 33/00 (2006.01)
Patent
CA 1134763
ABSTRACT OF THE INVENTION A process for producing 17-C-steroid-.alpha.-propionic acid compounds by microbial side chain degradation on 17-C-side chain steroid substrates, characterized in that (a) defect block mutant microorganisms producing steroid compounds having the 17-C-.alpha.-propionic acid residue even in the absence of inhibitors inhibiting the degradation of steroids and/or the growth are cultivated in an aqueous culture medium under aerobic conditions in the presence of the steroid substratum with accumulation of the 17-C- steroid-.alpha.-propionic acid compounds in the fermentation broth, and the 17-C- steroid-.alpha.-propionic acid compounds formed are isolated. The 17-C-steroid- .alpha.-propionic acid compounds produced by the process may be used as intermedi- ates in the preparation of useful steroids such as androstanedione and androsdienane.
325614
Hill Frank
Preuss Wolfgang
Schindler Joachim
Schmid Rolf
Struve Alfred
Fetherstonhaugh & Co.
Henkel Kommanditgesellschaft Auf Aktien
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