C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
260/18
C07J 43/00 (2006.01) C07J 21/00 (2006.01) C07J 41/00 (2006.01) C07J 51/00 (2006.01) C07J 53/00 (2006.01)
Patent
CA 1115691
A B S T R A C T The invention relates to novel spirooxazolidines re- presented by the general formula I' (I) wherein R1 is alkyl having from 1 to 4 carbon atoms, R2 is hydrogen, alkyl having from 1 to 4 carbon atoms, alkenvl havina from 1 to 4 carbon atoms, or dialkyl- phosphinlmethyl having in the alkyl moiety from 2 to 3 carbon atoms each. Z is one of the groups represented by the general formulee III to XIV (III) (IV) -2- (V) (VI) (VII) (VIII) (IX) (X) \ (XI) (XII) (XIII) (XIV) -4- Abstract Wherein R3 is hydrogen or methyl, R4 is fluorine, hydroxyl, acyloxy having from 1 to 3 carbon atoms, alkoxycarbonyloxy having from 1 to 4 carbon atoms, oxo, oximino or alkoximino having from 1 to 3 carbon atoms, R5 is oxo, oximino or alkoximino having from 1 to 3 carbon atoms, and R6 is alkyl having from 1 to 3 carbon atoms, with the proviso that if R1 is methyl and Z represents a group of the general formula XII, wherein R6 is methyl, the R2 is different from hydrogen or alkyl having from 1 to 4 carbon atoms - and stereoisomers thereof. A process for the preparation is also within the scope of this invention. The above compounds possess valuable pharmaceutical properties. Some representatives for example show remark- able anti-aldosterone activity.
298768
Borvendeg Janos
Hermann Ilona (nee Szente)
Schafer Inge E.
Solyom Sandor
Szilagyi Katalin (nee Farago)
Fetherstonhaugh & Co.
Richter Gedeon Vegyeszeti Gyar Rt
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