Steroid sulphatase inhibitors

Details Steroid sulphatase inhibitors Steroid sulphatase inhibitors

C - Chemistry, Metallurgy

07

J

C07J 31/00 (2006.01) A61K 31/565 (2006.01) C07J 51/00 (2006.01)

Patent

CA 2069483

3-Monoalkyl thiophosphonate steroid esters are disclosed as inhibitors of steroid sulphatase activity and as potential therapeutic agents in the treatment of oestrogen dependent cancers, in particular oestrone 3-monomethylthioghosphonate and dehydroepiandrosterone 3-monomethylthiophosphonate.

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