C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
530/13, 150/14,
C12N 15/12 (2006.01) C07K 14/705 (2006.01) C12N 1/21 (2006.01) C12N 15/73 (2006.01) C12Q 1/68 (2006.01) G01N 33/78 (2006.01)
Patent
CA 1320161
ABSTRACT A previously isolated hepatitis .beta. virus (HBV) integration in a 147 bp cellular DNA fragment linked to hepatocellular carcinoma (HCC) was used as a probe to clone the corresponding complemen- tary DNA from a human liver cDNA library. Nucleotide sequence analysis revealed that the overall structure of the cellular gene, which has been named hap, is similar to that of the DNA- binding hormone receptors. Six out of seven hepatoma and hepatoma-derived cell-lines express a 2.5 kb hap mRNA species which is undetectable in normal adult and fetal livers, but pres- ent in all non-hepatic tissues analyzed. Low stringency hy- bridization experiments revealed the existence of hap related genes in the human genome. The cloned DNA sequence is useful in the preparation of pure hap protein and as a probe in the detec- tion and isolation of complementary DNA and RNA sequences. The hap protein is a retinoic acid (RA) receptor identified as RAR-.beta..
586206
de The Hugues Blaudin
Dejean Anne
Marchio Agnes
Tiollais Pierre
Borden Ladner Gervais Llp
Institut Pasteur
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