Steroidal compounds as melanogenesis modifiers and uses thereof

Details Steroidal compounds as melanogenesis modifiers and uses thereof Steroidal compounds as melanogenesis modifiers and uses thereof

A - Human Necessities

61

K

A61K 31/56 (2006.01) A61K 8/49 (2006.01) A61K 31/58 (2006.01) A61P 17/00 (2006.01) A61Q 19/02 (2006.01)

Patent

CA 2722270

A method for the identification of compounds) that control melanin synthesis (melanogenesis), and the preparation and use of such compounds, and compositions and formulations thereof to modify (e.g., inhibit) melanin production are disclosed. A representative compound of the invention is defined by formula I: Me I The compounds may be prepared as pharmaceutical and cosmetic compositions, and in one embodiment, may be prepared in combination with each other, and with other melanogenesis inhibiting formulations. The compounds, compositions and formulations of the invention may be used for the prevention and treatment of conditions that are causally related to aberrant melanogenesis activity including, by way of non-limiting example, hyperpigmentation and others.

L'invention porte sur un procédé pour l'identification de composés qui commandent la synthèse de mélanine (mélanogénèse), et sur la préparation et l'utilisation de tels composés, et sur des compositions et des formulations de ceux-ci pour modifier (par exemple inhiber) la production de mélanine. Un composé représentatif de l'invention est défini par la formule I : Me I. Les composés peuvent être préparés sous forme de compositions pharmaceutiques et cosmétiques et, dans un mode de réalisation, peuvent être préparés en combinaison entre eux, et avec d'autres formulations inhibant la mélanogénèse. Les composés, compositions et formulations de l'invention peuvent être utilisés pour la prévention et le traitement d'états qui sont associés étiologiquement à une activité de mélanogénèse aberrante comprenant, à titre d'exemple non limitatif, lhyperpigmentation et autres.

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