C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 1/00 (2006.01) A61K 31/56 (2006.01) C07J 5/00 (2006.01) C07J 7/00 (2006.01) C07J 11/00 (2006.01)
Patent
CA 2073760
A novel method is provided for crystallizing organic and particularly steroidal substances. In particular, a crystallization method is provided whereby a predeterminable and homogenous particle size class can be obtained non-mechanically, and wherein a substance is dissolved in a ternary mixture consisting of a lipophilic solvent, a hydrophilic solvent and a surface-active agent at a temperature close to boiling, whereafter the mixture is allowed to cool to a temperature at which crystallization is initiated and the crystals thereby formed are separated. The method can be used for producing pharmaceutical active principles.
La présente invention se rapporte à un nouveau procédé de cristallisation de substances organiques et notament stéroi- diennes. La présente invention a spécifiquement pour objet un procédé de cristallisation que perment sans opération mécanique d'obtenir une classe granulumétrique homogène pré-déterminable, qui consiste en ce que l'on dissout une substance dans un mé- lange ternaire formé d'un solvant lipophile, d'un solvant hydrophile et d'un agent tensio-actif à une température proche de l'ébul- lition puis laisse le mélange revenir à une température ou la cristallisation s'amorce et sépare les cristaux formés. Production de principes actifs pharmaceutiques.
Laboratoire Theramex S.a.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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