Steroids

Details Steroids Steroids

C - Chemistry, Metallurgy

07

J

260/14

C07J 71/00 (2006.01) C07J 5/00 (2006.01) C07J 21/00 (2006.01)

Patent

CA 1086715

ABSTRACT OF THE DISCLOSURE This specification relates to the production of 9.alpha.-halo-11.beta.-hydroxy-corticosteroids, to intermediates used in the production of such steroids, and to the production of such intermediates themselves. The specification is particularly concerned with the production of such steroids having anti-inflammatory action, e.g. beclomethasone dipro- pionate. There is disclosed a new route for preparing 9.alpha.- halo-11.beta.-hydroxy-corticosteroids which involves the formation of novel 9.beta.,11.beta.-epoxy steroids which themselves may be con- veniently obtained from the corresponding 9.alpha.-bromo-11.beta.-hydroxy- corticosteroids.

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