Steroids esterified in position 17 and thioesterified in...

C - Chemistry – Metallurgy – 07 – J

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167/197, 260/81

C07J 31/00 (2006.01) A61K 31/57 (2006.01)

Patent

CA 1251784

ABSTRACT OF THE DISCLOSURE Compounds of formula : Image wherein A and B each represent, independently of each other, a straight-chained or branched alkyl group having from 1 to 6 carbon atoms or a phenyl group optionally mono- or polysubstituted by alkyl radicals having from 1 to 6 carbon atoms, alkoxy groups having from 1 to 6 carbon atoms or halogen T and U, independently of each other represent hydrogen atoms or together form 2 double bond, V is a hydrogen atom or a methyl group at the ?-position, W is a hydrogen atom or a halogen atom at the ?-position, X is a hydroxy group at the .beta.-position and Y is a hydrogen atom or X and Y may together represent an oxygen atom, and Z1 is a hydrogen atom, a methyl group at the ?- or .beta.-position, whilst Z2 is a hydrogen atom, or Z1 and Z2 together form a methylene group.These compounds have anti-inflammatory activity.

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