Steroids having a mixed androgenic and progestagenic profile

Details Steroids having a mixed androgenic and progestagenic profile Steroids having a mixed androgenic and progestagenic profile

C - Chemistry, Metallurgy

07

J

C07J 63/00 (2006.01)

Patent

CA 2549148

This invention provides 19-nor-D-homosteroids, having a mixed androgenic/progestagenic profile, which are orally active, prevent trabecular bone mineral density (BMD) loss, and which lack liver toxicity, having a structure according to the formula (I) wherein, R1 is O, or NOR, with R being hydrogen, (Cl-6)alkyl or (Cl-6)acyl, R2 is methyl or ethyl, and R3 is hydrogen or (C1-15)acyl.

Cette invention se rapporte à des 19-nor-D-homostéroïdes, ayant un profil androgénique/progestagénique mixte, qui sont oralement actifs qui préviennent la perte de densité minérale osseuse (BMD) de l'os trabéculaire et qui n'ont pas de toxicité pour le foie, ces composés ayant une structure représentée par la formule (I) dans laquelle R?1¿ représente O, ou NOR, R représentant hydrogène, alkyle (C¿l-6?) ou acyle (C¿l-6?), R?2¿ représente méthyle ou éthyle, et R?3¿ représente hydrogène ou acyle (C¿1-15?).

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