C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
195/19, 260/21,
C07J 9/00 (2006.01) A61K 31/56 (2006.01) C07J 5/00 (2006.01) C07J 7/00 (2006.01) C07J 17/00 (2006.01)
Patent
CA 1139743
ABSTRACT OF THE DISCLOSURE This invention provides a steroid of the general formula Image wherein X represents hydrogen, fluorine, chlorine or methyl, Y represents hydrogen, hydroxy, formyloxy or alkanoyloxy having up to 6 carbon atoms, Z represents hydrogen or methyl, V repre- sents methylene, ethylidene, hydroxymethylene or vinylidene, and R1 represents (C1-C6)alkyl optionally interrupted by an oxygen atom, and R2 represents hydrogen or (C1-C6)alkyl, or R1 and R2 together represent tetramethylene if Y represents hydroxy, formyloxy or alkanoyloxy. These compounds have good pharmaco- logical activity and also are useful intermediates for the pre- paration of 11.beta.-hydroxy steroids which themselves are useful medicaments.
320261
Dahl Helmut
Kennecke Mario
Schottle Ernst
Weber Alfred
Wieske Reinhold
Marks & Clerk
Schering Aktiengesellschaft
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