C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
195/19, 260/21,
C07J 5/00 (2006.01) C07J 7/00 (2006.01) C12P 33/08 (2006.01)
Patent
CA 1144538
ABSTRACT OF THE DISCLOSURE Novel corticoids of the general formula I Image wherein each Image bond is a single or double carbon-to-car- bon bond, X represents H, F, Cl or CH3, Y represents H and Z represents H, F or Cl or Y and Z together represent a carbon- to- carbon bond, V represents .beta.-hydroxymethylene, .beta.-chloro- methylene or carbonyl, W represents methylene, ethylidene or vinylidene, Q represents O or S, R1 represents C1-C8-alkyl optionally interrupted by O or represents benzyl and R2 repre- sents H or C1-C6-alkyl or R1 and R2 together represent tri- methylene or tetramethylene, and R3 represents H, F, Cl or free or esterified OH and processes for their manufacture. The novel corticoids of the formula I have an anti-inflammatory action and accordingly may be used as anti-inflammatory agents and may be made up with suitable carriers into pharmaceutical preparations. The Specification includes a microbiological process for the manufacture of 11.beta.-hydroxy-steroids of the pregnane series substituted in the 17.alpha.-position by an acetal group of the formula Image by fermenting a corresponding 11-desoxy-steroid with a culture of an 11.beta.-hydroxylating microorganism, especially a fungal culture of a strain of the genus Curvularia, and the use of some of the 11.beta.-hydroxy-steroids for the production of corres- ponding 11.beta.,17.alpha.-hydroxy-steroids.
320177
Annen Klaus
Dahl Helmut
Kapp Joachim-Friedrich
Kennecke Mario
Laurent Henry
Marks & Clerk
Schering Aktiengesellschaft
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