Steroids of the pregnane series substituted in the 17-...

Details Steroids of the pregnane series substituted in the 17-... Steroids of the pregnane series substituted in the 17-...

C - Chemistry, Metallurgy

12

P

195/30

C12P 33/08 (2006.01)

Patent

CA 1172590

ABSTRACT OF THE DISCLOSURE The present invention provides a microbiological process for the manufacture of 11.beta.-hydroxy-steroids of the pregnane series substituted in the 17.alpha.-position by an acetal group of the formula Image in which R1 represents an alkyl group containing 1 to 8 carbon atoms which may be interrupted by an oxygen atom or represents a benzyl group and R2 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, by fermenting a correspond- ing 11-desoxy-steroid with a culture of an 11.beta.-hydroxylating microorganism, especially a fungal culture of a strain of the genus Curvularia, and the use of some of the 11.beta.-hydroxy- steroids for the production of corresponding 11.beta.,17.alpha.-dihydroxy- steroids.

417837

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