Sterol-modified amphiphilic lipids

Details Sterol-modified amphiphilic lipids Sterol-modified amphiphilic lipids

C - Chemistry, Metallurgy

07

J

C07J 41/00 (2006.01) A61K 8/02 (2006.01) A61K 8/63 (2006.01) A61K 31/56 (2006.01) C07J 17/00 (2006.01) C07J 43/00 (2006.01) G01N 33/92 (2006.01) A61K 9/127 (2006.01)

Patent

CA 2705797

Disclosed are sterol-modified amphiphilic lipid compounds having two or more hydrophobic tails of which at least one is a sterol. Also disclosed are the processes for the synthesis of these compounds, compositions comprising such compounds, and the use of such compounds in delivery of an agent of interest, e.g., therapeutics, imaging agents, contrast materials for ultrasound applications, vaccines, biosensors, nutritional supplements and skin care products.

La présente invention concerne des composés lipidiques amphiphiles modifiés par un stérol ayant deux queues hydrophiles ou plus dont au moins une est un stérol. La présente invention concerne également les procédés de synthèse de ces composés, des compositions comprenant ces composés, et l'utilisation de ces composés pour la délivrance d'un agent d'intérêt, par exemple, des produits thérapeutiques, des agents d'imagerie, des matériaux de contraste pour des applications d'ultrasons, des vaccins, des biocapteurs, des suppléments nutritionnels et des produits de soin cutané.

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